January - March 2024, Volume 20, Issue 1

Novac RE, Florescu A, Gavril LG, Velicescu C

Rare Association between Hashitoxicosis, Basedow Disease and Papillary Thyroid Carcinoma

Acta Endo (Buc) 2024, 20 (1): 117-120
doi: 10.4183/aeb.2024.117

We present the case of a 32 yeas old male, diagnosed 7 years ago with Graves disease, with numerous recidives which needed anti-thyroid medication, with poor response (hypo to hyper-thyroid status, with high variations of TSH and FT4) whom after a period of remission (8 months, no treatment) came in for a polymorphic symptomatology sugestive for hyperthyroidism. The hyperthyroid state was confirmed he had high TRAb (31 UI/ml vs. <1.75 UI/ml) - on his last check in the detection rate of TRAb was under 0.3 UI/ml. The thyroid ultrasound revels on the left lobe a small mass of 0.8/0.8 cm, with EU-TIRADS score of 4, that was newly diagnosed. Postoperative histopathology revealed papillary microcarcinoma developed on Hashitoxicosis- pT1aN0, of 1 mm in the middle of left thyroid lobe. The particularity of this case consists in a long evolution of Graves disease with numerous relapses, the appearance of a thyroid nodule after 7 years in which they identified a papillary microcacinoma associated with Hashimoto thyroiditis and also the postoperative recovery that was slowed by the parathyreoprive tetany.

Keywords: Graves, Hashitoxicosis, papillary thyroid carcinoma.

Correspondence: Roxana Elena Novac MD, Emergency Hospital Moinesti, Endocrinology, 1st Zorilor Street, Moinesti, Bacau, 600230, Romania, E-mail: dr.roxananovac@gmail.com