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Romanian Academy
The Publishing House of the Romanian Academy
ACTA ENDOCRINOLOGICA (BUC)
The International Journal of Romanian Society of Endocrinology / Registered in 1938in Web of Science Master Journal List
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Acta Endocrinologica (Buc)
Bolu F, Bolu S
Congenital Hypothyroidism Screening Results in the Turkish Province of Adiyaman in 2015-2020
Acta Endo (Buc) 2024, 20 (2): 201-206doi: 10.4183/aeb.2024.201
Context. Congenital hypothyroidism (CH) is one
of the most common preventable causes of intellectual
disability, and can be diagnosed in the early period through
neonatal screening programs.
Objective. The purpose of this study was to
determine the prevalence of CH and recall rates in the
province of Adıyaman.
Design. This retrospective study evaluated the
data of newborn screening program in Adıyaman province
between January 2015 and December 2020.
Subjects and Methods. The thyroid-stimulating
hormone (TSH) cut-off value in the screening program is 5.5
mIU/L and TSH values lower than 5.5 mIU/L are regarded
as normal. Babies with TSH levels exceeding 5.5 mIU/L
were defined as ‘recalled’. TSH measurements and clinical
diagnoses of the recalled babies were evaluated.
Results. TSH was <5.5 mIU/L in 62270 (90.08%) of
the newborns, 5.5-20 mIU/L in 6114 (8.84%), and >20 mIU/L
in 742 (1.07%). Venous T4-TSH values were normal in 673
of the 742 babies with TSH levels exceeding 20 mIU/L, while
63 babies were diagnosed with CH. Heel blood results were
normal in 5880 of the 6114 babies with TSH levels of 5.5-20
mIU/L and for whom repeat heel blood was requested. TSH
levels in repeat heel blood were >5.5 mIU/L in 184 babies and
93 of them were diagnosed with hypothyroidism. The recall
rate among babies undergoing heel blood TSH measurement in
the province of Adıyaman was 9.9%. 156 babies were started
on thyroid replacement therapy with diagnoses of CH. The
incidence of babies diagnosed with hypothyroidism was 1/443.
Conclusion. According to the CH screening
results, the recall rate and incidence of CH in the province
of Adıyaman were higher than the global general figures.
Both the low TSH threshold value employed in neonatal
hypothyroidism screening and the province falling within
the iodine deficiency region may account for this.
Keywords: newborn, screening program, congenital hypothyroidism.
Correspondence: Filiz Bolu MD, Bolu Provincial Health Directorate, Department of Public Health, Borazanlar Mah. No:58 Postal Code:14100 Merkez, Bolu, Turkey, E-mail: bolufiliz@gmail.com