October - December 2024, Volume 20, Issue 4

Rao Z, Zhang Y, Luo C, Zhu C

Exploring the Link between Systemic Immunity-Inflammation Index and Obesity in the US Population: Nhanes Study Insights (2005–2020)

Acta Endo (Buc) 2024, 20 (4): 455-464
doi: 10.4183/aeb.2024.455

Objective. To explore the correlation between the systemic immunity-inflammation index (SII) and obesity, utilizing data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2020. Methods. This cross-sectional study included 137,888 adult participants with complete data on SII and obesity. SII was calculated using the formula: platelet count multiplied by the neutrophil count divided by the lymphocyte count. Obesity was defined as a body mass index (BMI) exceeding 30 kg/m2. Results. Multivariate linear regression analysis showed a significant positive correlation between SII and obesity (β = 0.19, 95% CI: 0.18, 0.20). Factors such as age, sex, education level, and smoking status significantly influenced this correlation. However, race, income-topoverty ratio, hypertension, and diabetes did not significantly interact with the observed relationship (interaction p-value > 0.05). Conclusion. The study highlights a substantial link between elevated SII levels and the prevalence of obesity, indicating the potential of SII as a biomarker in obesity research. Further large-scale prospective studies are needed to better understand the role of SII in the pathophysiology of obesity.

Keywords: Systemic immunity-inflammation index, Obesity, NHANES, Inflammation.

Correspondence: Yiming Zhang, Department of Endocrinology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, 324000, Zhejiang, China, E-mail: zhangym1611@wmu.edu.cn