January - March 2024, Volume 20, Issue 1

Hengky A, Pratama KG, Tandarto K

Mortality and Cardiovascular Risk Reduction after Reversion of Prediabetes to Normoglycemia: A Systematic Review

Acta Endo (Buc) 2024, 20 (1): 74-79
doi: 10.4183/aeb.2024.74

Introduction. It is unclear whether reversion to normoglycemia decreases overall cardiovascular events and all-cause mortality risk in the long term. We aim to investigate the magnitude of change in cardiovascular risk and mortality in patients who reverted from a prediabetes state. Methods. Three electronic databases, including PubMed, Proquest, and EBSCOHost databases, were utilized. A manual hand search of articles was also done. We selected studies that measure cardiovascular risk and all-cause mortality risk after reversion from prediabetes to normoglycemia. The following terms and its variant were used in the search strategy: ‘reversion,’ ‘prediabetes,’ ‘normoglycemia,’ cardiovascular risk,’ and ‘mortality.’ Results. Seven studies with a total of 73,845 participants were obtained. Most studies suggest that reversion of prediabetes reduced the cardiovascular and allcause mortality risk (RR: 0.50 – 0.78) compared to persistent prediabetes state or progression to diabetes with long-term follow-up ranging from 5 to 12 years, while two studies did not show significant association in CVD and all-cause morality risk. Conclusion. Although there were mixed results regarding if prediabetes poses a higher risk than normoglycemia for cardiovascular events and all-cause mortality, measures to normalize blood glucose for prediabetes should still be advocated.

Keywords: prediabetes, normoglycemia, reversal, cardiovascuiar risk, mortality.

Correspondence: Antoninus Hengky MD, Atma Jaya Catholic University of Indonesia - Pluit Campus, Jl. Pluit Raya II, Jakarta, 14440, Indonesia, E-mail: antoninushengky@gmail.com