ACTA ENDOCRINOLOGICA (BUC)

Context. Comparison of GnRH analogues and their impact on IVF treatment to improve pregnancy outcome.\r\nObjective. To compare the effects of GnRH agonists and GnRH antagonists on pregnancy rates.\r\nDesign. A total of 458 women who had embryo transfers completed were analyzed retrospectively in a university\r\nhospital setting.\r\nMethods. Comparative data were gathered on pregnancy rates, FSH dosage, and number of follicles, retrieved oocytes\r\nand embryos.\r\nResults. The use of GnRH agonist showed a strong association with the number of follicles (GnRH antagonist: 11.45; GnRH agonist: 15.17), oocytes retrieved (GnRH antagonist: 10.66; GnRH agonist: 13.68) and embryos transferred (GnRH antagonist: 2.54; GnRH agonist: 2.89) (p<0.01). The use of GnRH antagonist showed a significant association with &#946;-\r\nhCG > 5 mIU/mL pregnancy (GnRH antagonist 30.8%; GnRH agonist: 21.8%) (p<0.05). Ongoing pregnancy rates between\r\nthe two GnRH analogues showed no statistically significant differences (GnRH antagonist 72.1%; GnRH agonist: 64.1%)\r\n(p>0.05).\r\nConclusion. On the basis of current evidence, it is still unclear which GnRH analogue is the first choice for achieving a higher rate of pregnancy.