ACTA ENDOCRINOLOGICA (BUC)

The International Journal of Romanian Society of Endocrinology / Registered in 1938

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Year Volume Issue First page
10.4183/aeb.
Author
Title
Abstract/Title
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  • General Endocrinology

    Koumoundourou D, Michail G, Zervoudis S, Maragoudakis ME, Tsopanoglou N, Kourounis G, Ravazoula P

    Assessment of protease activated receptor-1 (PAR-1) expression in breast cancer patients and correlation with clinicopathological parameters

    Acta Endo (Buc) 2005 1(4): 383-392 doi: 10.4183/aeb.2005.383

    Abstract
    Previous studies have correlated the expression of PAR proteins with breast cancer invasiveness. The scope of this study was to evaluate the expression of PAR-1 in human breast cancer specimens and investigate possible correlations with tumor size, grade and lymph node status, as well as covariations with estrogen and progesterone receptors, c-erbB-2 protein and lysosomal protease Cathepsin D. Formalin-fixed paraffin-embedded sections of 75 mastectomy specimens deriving from patients with primary breast carcinomas were implemented. Expression of PAR-1 was detected employing immunohistochemical assays utilizing a goat polyclonal PAR-1 antibody. The granular pattern of cytoplasmic immunoreaction was considered indicative for the protein?s expression. Statistical assessment was performed using SPSS 13.0 statistical package, Pearson?s correlation, &#967;2 and Fisher?s exact test. Expression of PAR-1 protein had a statistically significant correlation (p<0.001) with tumor grade, while in invasive tumors a similar relationship (p<0.001) was documented between PAR-1 expression and presence of positive axillary lymph nodes. However, PAR-1 expression did not exhibit a significant correlation with tumor size or with the expression of ER, PR, c-erbB-2, or Cathepsin D molecules. PAR-1 possesses a role in tumor invasion and contributes to the metastatic potential of certain types of breast carcinomas. The disassociation between expression of PAR-1 and that of the ER, PR, c-erbB-2, or Cathepsin D might imply participation in alternative pathways of malignant transformation and tumor progression.
  • Images in Endocrinology

    Chai G, Wang Y, Ji Q

    Covid-19 Patient with Combined Bilateral Adrenal Hemorrhage

    Acta Endo (Buc) 2023 19(4): 530-531 doi: 10.4183/aeb.2023.530