ACTA ENDOCRINOLOGICA (BUC)

Context. Regular training program is recognized to play a key role in chronic low-grade inflammation in obese patients. Objective. The aim of this study was to evaluate the effects of a continued aerobic training on serum Interleukine-10 (IL-10) as anti-inflammatory cytokine in obese women. Subjects and Methods. Thirty non-trained obese women aged 30-40 years with BMI 30-36 (kg/m2) participated in the study and divided into exercise (n=15) and control groups. Exercise subjects completed a 6 weeks aerobic training at 60-75% of heart rate max and continued to 12 weeks. Anthropometrical markers and fasting blood samples were collected of all subjects at pre, mid (6 weeks) and post training (12 weeks) for measuring serum IL-10. Data were analyzed using repeated measures ANOVA. Significance was accepted at P<0.05. Results. At baseline (pre training), there were no differences in the age, body weight and other anthropometrical indexes also in serum IL-10 between the two groups (p>0.05). Six and 12 weeks of aerobic training resulted in a significant decrease in body weight and other anthropometrical indexes and a significant increase in IL-10 compared to baseline (p<0.05). No significant difference was observed in serum IL-10 between 6 and 12 weeks aerobic training (p=0.361). There were no changes in all variables in the Control group (p>0.05). Conclusion. Based on this data we concluded that anti-inflammatory effects of long term aerobic training can be attributed in part to IL-10 but further studies over other markers of inflammatory profile are necessary in order to sustain the anti-inflammatory effect of aerobic training.