The International Journal of Romanian Society of Endocrinology / Registered in 1938

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  • Endocrine Care

    Larg MI, Barbus E, Gabora K, Pestean C, Cheptea M, Piciu D

    18F-FDG PET/CT in Differentiated Thyroid Carcinoma

    Acta Endo (Buc) 2019 15(2): 203-208 doi: 10.4183/aeb.2019.203

    Aim. Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) become an important tool in oncology by combining the metabolic information from 18F-FDG PET with the morphological information of CT. The main objective of this study was to assess the diagnostic value of PET/CT in patients with differentiated thyroid carcinoma (DTC). Material and Methods. We analyzed 173 PET/CT scans of patients with DTC presenting elevated thyroglobulin (Tg) levels, negative Tg-antibodies levels, negative Iodine-131 whole-body scanning (I-131 WBS) and without any signs of clinical or other imaging technique for tumor recurrence/metastases. Results. PET/CT scans were positive in 38% of cases (65/173). The sensitivity, specificity, positive predictive values and the accuracy of PET/CT imaging were 88.09%, 98.6%, 93.1% respectively 96.53%. After the PET/CT scan 29 patients underwent surgery, 24 of them continued radio-iodine therapy, 5 patients initiated tyrosine kinase inhibitors treatment and external radiotherapy. Conclusion. 18F-FDG PET/CT is a valuable imaging technique which has the capability of identifying those cases of thyroid recurrence/metastases with elevated Tg levels and negative I-131 WBS. The treatment strategy was changed in 89.2% cases of positive PET/CT scans which shows us that 18F-FDG PET/CT imaging should be integrated into the follow-up programs for DTC patients.
  • Images in Endocrinology

    Piciu D, Larg MI, Barbus E, Piciu A

    Unusual Peritoneal and Muscular Metastases in an Aggressive and Extensive Case of Anaplastic Thyroid Cancer on 18F-FDG PET/CT

    Acta Endo (Buc) 2018 14(3): 408-409 doi: 10.4183/aeb.2018.408