The International Journal of Romanian Society of Endocrinology / Registered in 1938

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  • Endocrine Care

    Pop GD, Duncea I, Georgescu C, Hazi G, Dragotoiu G, Leucuta DC

    Estimation of 25(OH)D levels required for maintaining a normal bone turnover in healthy aging men

    Acta Endo (Buc) 2007 3(1): 31-44 doi: 10.4183/aeb.2007.31

    Introduction. Vitamin D deficiency has been proven to have a deleterious effect on bone remodeling and bone mineral density, by inducing secondary hyperparathyroidism. The lack of a present consensus on optimal serum 25(OH)D levels required for the preservation of physiologic bone metabolism renders its follow-up difficult.\r\nMaterials and Methods. The cross-sectional study was performed on a sample of 69 healthy men aged 50-70. Serum 25(OH)D, total testosterone, sex hormone binding globulin, s-CTX (Crosslaps), and osteocalcin were assessed. BMD was measured by DXA at lumbar spine and hip levels. Statistical relationships between these parameters were calculated.\r\nResults. We found a significantly negative correlation between 25(OH)D and s-CTX (r = -0.30. p<0.05), but not between 25(OH)D and osteocalcin, although s-CTX correlated positively with osteocalcin (r = 0.49, p<0.001). Serum CTX was negatively correlated with lumbar BMD (r = -0.35, p<0.001), while osteocalcin was negatively correlated with total hip BMD (r = -0.26, p<0.01). Comparing mean s-CTX levels in insufficient and sufficient subjects at different cut-off points for 25(OH)D, significant differences appeared the strongest at 60 ng/ml. The percentage of 25(OH)D deficient or insufficient subjects was 50.7% at a 30 ng/ml cut-off point.\r\nConclusions. The results of the present study confirm the benefit in maintaining a normal bone turnover offered by serum 25(OH)D in the upper normal range. The large percentage of patients with vitamin D insufficiency reinforce the necessity of a specific follow-up and of epidemiologic studies dedicated to our geographic area.
  • Endocrine Care

    Scânteie CL, Leucuta DC , Ghervan CM

    Quality of Life in Patients with Acromegaly – a Romanian Single Center Cross-Sectional Study

    Acta Endo (Buc) 2021 17(1): 42-50 doi: 10.4183/aeb.2021.42

    Context. Acromegaly, a severe condition characterized by excessive and unmodulated secretion of growth hormone, leads to morphologic disturbances and multisystem complications. Objective. The purpose of this study was to evaluate the quality of life (QOL) in patients with acromegaly compared to matched obese patients. Design. This was an observational cross-sectional study. Subjects and methods. We enrolled 49 patients with acromegaly and 49 obese patients. AcroQoL (acromegaly QoL questionnaire) was applied to all patients and IGF-1 (type 1 insulin-like growth factor 1) was measured. Results. Patients with acromegaly had a worse QoL compared to patients with obesity (score= 77(53-86) vs. 96(90- 102), p˂0.001). In the group of patients with acromegaly, there was no difference in the QoL regarding the activity of the disease (active, controlled, or cured). Men had a higher AcroQoL score than women (score= 88(55-95) vs. 74(52.75- 82), p=0.02), but there was no difference between patients with microadenomas and the ones with macroadenomas (score= 82(66-88.5) vs. 73(55-83), p=0.136). The most frequent complications were cardiovascular complications (81.63%), articular complications (73.46%), dyslipidemia (65.30%) and digestive complications (63.26%). Conclusions. Despite complex treatment and hormonal control, the presence of complications reduces the quality of life in patients with acromegaly, even when compared with obese patients.
  • Endocrine Care

    Valean C, Tatar S, Nanulescu M, Leucuta A, Ichim G

    Prevalence of obesity and overweight among school children in Cluj-Napoca

    Acta Endo (Buc) 2009 5(2): 213-219 doi: 10.4183/aeb.2009.213

    Background. A rising trend in obesity among children has been observed in recent years\r\nin most countries. The majority of obese children will become obese adults having an increased\r\nrisk for chronic diseases associated with obesity, with a negative impact on their lifespan.\r\nObjective. Assesing the obesity prevalence among school children in Cluj-Napoca.\r\nMethods. The study included 7904 school children of all grades (grade 1 to grade 12) from\r\n20 schools in Cluj-Napoca. The weight, height and body mass index (BMI) were recorded for\r\neach child. Using the BMI percentile, they were classified as: normal (BMI < 85th percentile),\r\noverweight (BMI between 85th and 95th percentile) or obese (BMI > 95th percentile). BMI average\r\nand standard deviation have been calculated per age groups and sex.\r\nResults. 8.29% of school children in Cluj-Napoca are obese, while 12.84% of them are\r\noverweight. The difference between sex groups is statistically significant with boys more likely to\r\nbe obese or overweight than girls (p<0.0001). The highest prevalence has been observed among\r\nthe 6-10 years age group, while teenagers have recorded the lowest prevalence figures.\r\nConclusion. Data derived from this study would place Romania among the countries\r\nwith an average prevalence of obesity. However, extending such studies at national level\r\nwould provide more accurate data about obesity prevalence in Romania.
  • Endocrine Care

    Valean C, Ichim G, Tatar S, Samasca G, Leucuta A, Nanulescu MV

    Prevalence of metabolic syndrome and serum profile of adipokines (leptin and adiponectin) in children with overweight or obesity

    Acta Endo (Buc) 2010 6(3): 343-354 doi: 10.4183/aeb.2010.343

    Background. Metabolic syndrome is an important risk factor for cardiovascular diseases. \r\nObjective. Evaluating the prevalence of metabolic syndrome and serum profile of adipokines in children with overweight or obesity. \r\nMethods. Sixty two children were included in the study, with a body mass index (BMI) that exceeded 85th percentile. Waist circumference and blood pressure (BP) were recorded, followed by the determination of: glucose, cholesterol, triglycerides, HDL cholesterol, insulin, adiponectin and leptin. The insulin resistance was then calculated. \r\nResults. Of the 52 children included, 28,8% have met the criteria for diagnosis of metabolic syndrome. BMI and BP values were higher in children with metabolic syndrome as well as the values of leptin (69.59 ? 50;89 vs. 58.44 ? 42.28 ng / ml) and insulin resistance (1.65 ? 0 ,74 vs. 1.41? 0.78). We could found a positive correlation, statistically significant between BMI and serum leptin (r = 0.32, p =0.02), BMI and insulin (r = 0.33, p = 0.01) and BMI and insulin resistance (r = 0.33, p = 0.01). \r\nConclusion. Metabolic syndrome has a high prevalence in childhood obesity. The adipokines seem to have a very good correlation with the clinical and bioumoral features of the metabolic syndrome.