The International Journal of Romanian Society of Endocrinology / Registered in 1938

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  • Images in Endocrinology

    Suvoiala Stamate A, Galoiu S, Gherlan I, Popa O, Aldoescu S, Brezean I, , Poiana C

    Morris’ Syndrome

    Acta Endo (Buc) 2015 11(4): 530-531 doi: 10.4183/aeb.2015.530

  • Case Series

    Capatina C, Vintila M, Gherlan I, Dumitrascu A, Caragheorgheopol A, Procopiuc C, Ciubotaru V, Poiana C

    Craniopharyngioma - Clinical And Therapeutic Outcome Data in a Mixed Cohort of Adult and Paediatric Cases

    Acta Endo (Buc) 2018 14(4): 549-555 doi: 10.4183/aeb.2018.549

    Background. Craniopharyngiomas are benign but locally invasive tumours of the sellar region that arise from ectopic embryonic remnants of Rathke's pouch, affecting both children (adamantinomatous type -aCP) and adults (papillary type -pCP) and associated with significant morbidity. Objective. To study the clinical presentation of CRF as well as the posttreatment evolution of craniopharyngioma in children versus adults in a large mixed cohort. Material and methods. We performed a retrospective review of CRF patients evaluated in the National Institute of Endocrinology in Bucharest between 1990 and 2016. Results. A total of 107 patients (72 adults, 35 children) with a mean follow-up of 6.2 years were included. The presenting symptoms were mostly headache, visual impairment, symptoms of hypopituitarism, diabetes insipidus. Some symptoms or hormonal abnormalities were significantly more prevalent in the children group (p<0.05): nausea/ vomiting (47.8% vs 16.7%), photophobia (21.7% vs 5.6%), diabetes insipidus(28.5% vs 8.3%), GH deficiency (68.8% vs 17.1%). Impaired visual acuity (67.6%of cases) or visual fields (71.4%) were more frequent in adults compared to children (44.1%; 51.6%). The tumor dimensions were similar in both groups (3.05± 1.05 cm in children; 2.7± 1.07 cm in adults). Massive suprasellar extension reaching the third ventricle was frequently present in all cases. All cases underwent surgery but only a minority of those not cured received postoperative adjuvant radiotherapy. Frequent postoperative complications were: aggravation of the endocrine deficit (>80% of cases in both groups needed chronic replacement therapy), central diabetes insipidus (68.2% children, 34.3% of adults). Conclusions. Despite similar tumor dimensions and extension compared to adults, craniopharyngioma in children is more frequently associated with signs of intracranial pressure. The results and complications of treatment are similar in adults and children
  • Endocrine Care

    Paun DL, Petris R, Terzea D, Paun S, Ganescu R, Carsote M, Dumitrache C, Poiana C

    Immunohistochemistry with Inhibin Alpha, Melan A and MNF 116 in Adrenal Tumors

    Acta Endo (Buc) 2013 9(4): 565-573 doi: 10.4183/aeb.2013.565

    Aim. The goal was to study immunostaining with Inhibin alpha, Melan- A and MNF 116 in tumors located in the adrenals (benign adrenocortical tumors and metastatic lesions in the adrenal gland) because sometimes pathology cannot distinguish between the two. Patients and Methods. We included 35 patients with benign adrenal tumors and 15 patients with adrenal metastases from nonadrenal tumors submitted to laparoscopic (n=40) or classical (n=10) surgery. In our study we have explored immunostaining with inhibin α-subunit, melan-A, MNF 116 in adrenocortical tumors and metastatic lesions in the adrenal gland in order to make the distinction between primary adrenal cortical lesions and metastatic lesions. Results. All nonsecreting adrenocortical adenomas were stained with inhibin α-subunit and melan-A, but did not stain with MNF 116. All adrenal metastases stained with MNF 116 but were negative for inhibin α-subunit and melan-A with the exception of the 2 melanomas, which stained for melan-A. Conclusion. Inhibin α-subunit and melan-A were sensitive for benign adrenocortical tumors, while MNF 116 was sensitive for metastases from extraadrenal tumors.
  • Images in Endocrinology

    Poiana C, Baculescu N

    Unusual Metastasis of Thyroid Carcinoma

    Acta Endo (Buc) 2011 7(4): 575-575 doi: 10.4183/aeb.2011.575