ACTA ENDOCRINOLOGICA (BUC)

The International Journal of Romanian Society of Endocrinology / Registered in 1938

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Year Volume Issue First page
10.4183/aeb.
Author
Title
Abstract/Title
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  • General Endocrinology

    Cui Z, Qin Q, Chen P, Wang J, Zhang S, Mei X, Xie B, , Wang S

    Effect of Dorsomedial Hypothalamus Neuropeptide Y Knockdown on Hepatic Insulin Sensitivity

    Acta Endo (Buc) 2019 15(1): 25-31 doi: 10.4183/aeb.2019.25

    Abstract
    Objective. In this study we investigated the effect of dorsomedial hypothalamus (DMH) neuropeptide Y (NPY) knock-down on hepatic insulin sensitivity in high-fat (HF) diet-fed rats. Methods. Forty-eight Sprague-Dawley rats were randomly assigned to receive bilateral DMH injections of adeno-associated virus AAVshNPY or AAVshCTL and then accessed to regular chow. Five weeks after viral injection, half rats in each group were given access to the HF diet. At 16 weeks, rat livers were collected. Insulin receptor substrate-1 (IRS-1) and phosphoinositide 3-kinase (PI3K) mRNA expression was measured by qRT-PCR. Blood glucose levels were measured by the oxidase method, serum insulin, triglyceride, and TC levels were measured by Elisa. Pathological changes in the liver were assessed by hematoxylin-eosin (HE) staining. AKT, p-AKT, and GSK-3 levels were measured by western blotting. Results. Compared with AAVshCTL-injected rats, AAVshNPY-injected rats showed a significant decrease in blood glucose concentrations; serum insulin, triglyceride, and TC; HOMA-IR; and IRS-1 and PI3K mRNA levels (P<0.05). ISI, GSK-3, and p-AKT levels were significantly increased (P<0.05). HE staining showed that AAVshNPYinjected rats fed the HF diet had mild fatty degeneration. Conclusion. These results suggest that DMH NPY knock-down improves hepatic insulin sensitivity in HF diet-fed rats by activating the hepatic PI3K/AKT insulin signalling pathway.
  • Images in Endocrinology

    Huang SP, Zhou HW, Li D, Hu MR, Qin C

    A Giant Non-Functional Parathyroid Cyst

    Acta Endo (Buc) 2020 16(2): 262-262 doi: 10.4183/aeb.2020.262

  • Images in Endocrinology

    Yu J, Qin C, Huang S, Ye X, Meng N

    Treatment of Giant Juvenile Breast Fibroadenoma by Single Hole Breast Endoscopy: a Case Report

    Acta Endo (Buc) 2021 17(4): 552-553 doi: 10.4183/aeb.2021.552