The International Journal of Romanian Society of Endocrinology / Registered in 1938

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  • Notes & Comments

    Romanian National Symposium of Psychoneuroendocrinology -

    Selected Abstracts of the XVth Romanian National Symposium of Psychoneuroendocrinology

    Acta Endo (Buc) 2008 4(4): 479-502 doi: 10.4183/aeb.2008.479

  • Clinical review/Extensive clinical experience

    Ciobanu DM, Bala C, Rusu A, Roman G

    Amino Acids Metabolomic Signature of Blood Pressure Variability in Type 2 Diabetes

    Acta Endo (Buc) 2022 18(4): 494-501 doi: 10.4183/aeb.2022.494

    Context. Accumulating data supports the key role of disrupted amino acids (AAs) metabolism in diabetes. Conflicting data regarding the relevance of serum AAs in diabetes and hypertension suggest that their relationship needs further investigation. Objective. To investigate serum AAs as biomarkers of increased BP variability evaluated during 24-hour ambulatory BP monitoring in the presence of type 2 diabetes. Design. Cross-sectional. Subjects and Methods. We analyzed serum AAs using targeted metabolomics (ultrahigh-performance liquid chromatography/mass spectrometry) in patients with type 2 diabetes (n=80). BP variability was assessed using 24-hour ambulatory BP monitoring. Participants were divided into two groups based on the 24-hour diastolic BP variability median value. Results. Aspartic acid, isoleucine, leucine, and phenylalanine were significantly lower, while glutamine was significantly higher in the group with higher diastolic BP variability (p-value <0.05 and variable importance in the projection >1). Corresponding pathways identified as disrupted in patients with diabetes and a higher 24-hour diastolic BP variability were phenylalanine, tyrosine, and tryptophan biosynthesis, phenylalanine metabolism, and alanine, aspartate, and glutamate metabolism (pathway impact value >0). Conclusions. We identified specific changes in serum AAs and target AAs pathways in relation to increased 24-hour diastolic BP variability in patients with type 2 diabetes.
  • Case Report

    Valea A, Muntean V, Domsa I, Zaharia R, Roman C, Moisiuc P, Duncea I

    Bilateral anorchia

    Acta Endo (Buc) 2009 5(4): 519-524 doi: 10.4183/aeb.2009.519

    Anorchia is a syndrome characterized by unilateral or bilateral absence of testicular tissue.\r\nAt puberty, growth and development are normal but secondary sexual development fails to\r\noccur if anorchia is bilateral.\r\nWe present the case of a 21 year-old male with a late diagnosis of bilateral anorchia. The\r\ndiagnosis was suggested by a bilateral empty scrotum, in a patient with male phenotype and\r\npoor secondary sexual development and established by karyotype analysis, hormonal profile\r\nand surgical exploration. The lack of testosterone response to hCG stimulation is the hormonal\r\nhallmark of bilateral congenital anorchia. In the absence of any information about germinal cell\r\npresence, bilateral excision of the testicular nubbins, implantation of testicular prostheses and\r\nhormonal replacement therapy were indicated.
  • Notes & Comments

    Romanian National Symposium of Psychoneuroendocrinology -

    Selected Abstracts of the xvth Romanian Congress of Endocrinology

    Acta Endo (Buc) 2007 3(4): 519-530 doi: 10.4183/aeb.2007.519