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ACTA ENDOCRINOLOGICA (BUC)
The International Journal of Romanian Society of Endocrinology / Registered in 1938in Web of Science Master Journal List
Acta Endocrinologica(Bucharest) is live in PubMed Central
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Editorial
Castinetii F, Conte-Devlox B, Brue T
Glucocorticoid receptor antagonists: a therapeutic tool in Cushing's syndrome...to be handled with careActa Endo (Buc) 2010 6(1): 91-94 doi: 10.4183/aeb.2010.91
Abstract- -
Case Report
Panourgias E, Zervoudis S, Panagi G, Koureas A, Ivanov S
Unilateral breast edema simulating inflammatory carcinoma of the breastActa Endo (Buc) 2006 2(1): 91-94 doi: 10.4183/aeb.2006.91
AbstractUnilateral breast edema is an uncommon semiologic finding. Lots of etiologies could occur: acute mastitis, acute inflammatory breast cancer, after radiotherapy for breast cancer, lymphatic metastasis and malignant lymphoma. Rarely congestive heart failure could lead to breast edema, since the phenomenon is usually bilateral. In contrast unilateral breast edema from cardiologic etiology is exceptional. We report a case of an 86 year-old woman suffering from congestive heart failure who presented with unilateral breast edema and an imaging appearance of inflammatory breast carcinoma on mammography. The clinical and mammography appearance is described, the differential diagnosis discussed. After the cardiologic treatment, the unilateral breast edema disappeared, and the patient recovered. -
Case Report
Stanescu Popp A, Anca I, Bica V, Ionesti C, Alexe G
Association of celiac disease and Turner syndromeActa Endo (Buc) 2007 3(1): 93-100 doi: 10.4183/aeb.2007.93
AbstractTurner syndrome is one of the genetic disorders studied on their association with celiac disease. We present a 27 year old female with an association of Turner syndrome and celiac disease. Gluten intolerance presenting with atypical extraintestinal symptoms (recurrent aphthous stomatitis, iron-deficient anemia, short-stature) was confirmed by intestinal biopsy showing flat small bowel mucosa (Marsh IIIc lesion) and a peripheral lymphocyte karyotype analysis revealed a Turner syndrome determined by isochromosome 46,X,i (Xq) structural abnormality. Our patient fits perfect into this variant of Turner’s Syndrome presenting at least one autoimmune disorder (celiac disease) and hearing loss. Her clinical, biological and immunological disturbances caused by two irreversible disorders have a poor outcome in the absence of gluten-free diet associated with adequate endocrinologic treatment and need sustained long-term follow - up for a good quality of life. -
Editorial
Coculescu M
Vassopressin in intensive care unitActa Endo (Buc) 2009 5(1): 93-98 doi: 10.4183/aeb.2009.93
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Case Report
Grigore M, Vulpoi C, Preda C, Martiniuc V, Vasiliu I, Gorduza V
Using HD live Technology to Diagnose Turner Syndrome in the First Trimester of Pregnancy. Case ReportsActa Endo (Buc) 2015 11(1): 93-98 doi: 10.4183/aeb.2015.93
AbstractAbstract Introduction. Turner syndrome, a genetic disorder with an exclusively feminine phenotype, is caused by complete or partial X monosomy in some or all cells. Although the condition is usually diagnosed after birth, now, it is possible to detect the syndrome prenatally. Case reports. We present two cases of Turner syndrome diagnosed during the first trimester of pregnancy. The condition was suspected because of several ultrasound signs and was confirmed in both cases after an invasive prenatal technique. In one case, the fluorescent in situ hybridization technique was applied. In the other case, the chromosomal anomaly was detected using the G banding technique. Threedimensional ultrasound and HDlive technology were extremely useful in helping the patients to better understand the fetal pathology and accept an invasive procedure as a final step in establishing the diagnosis. Conclusion. These cases demonstrate the importance of using ultrasound as a screening method to detect suspected cases of Turner syndrome, however, the disorder needs to be confirmed with chromosomal analysis after performing an invasive prenatal technique. -
Case Report
Tuli G, Munarin J, Mignone F, Leone A, de Sanctis L
Cytomegalovirus Infection and Congenital Hypothyroidism: Possible AssociationActa Endo (Buc) 2022 18(1): 93-96 doi: 10.4183/aeb.2022.93
AbstractBackground. Congenital hypothyroidism (CH) is the most common congenital endocrine disease with reported high prevalence of associated congenital anomalies which are also present in case of congenital cytomegalovirus (cCMV) infection. Subjects and Methods. We present two cases of newborns cCMV infection with CH. In the first case thyroid agenesis was diagnosed and cCMV infection was also confirmed for the hypotonia persistence after L-thyroxine treatment. In the second case thyroid dyshormonogenesis was diagnosed with maternal CMV serological conversion in the first trimester of gestation and confirmed post-neonatal infection. Incidence of CH has increased in the Italian region of Piedmont in the years 2014-2019 up to 1:1090 with higher incidence of cCMV infection in the babies with diagnosis of CH (12/1000 vs. 5-7/1000 in the newborns without CH). To our knowledge, no data on the association of cCMV infection with a CH condition have been reported in the literature to date. Conclusions. The described cases could be useful to alert caregivers in case of maternal seroconversion to avoid maternal and foetal hypothyroidism. On the other hand, when the clinical condition of newborns with CH diagnosis do not improve after l-thyroxine treatment, it might be important to consider cCMV infection. -
Case Report
Grigorie D, Sucaliuc A, Ranetti A, Dobrea C, Bancos I
Primary Bilateral Adrenal Lymphoma Presenting with Impending Adrenal CrisisActa Endo (Buc) 2024 20(1): 93-96 doi: 10.4183/aeb.2024.93
AbstractPrimary bilateral adrenal lymphoma is a very rare cause of adrenal insufficiency. We report the case of a 63-year-old woman who presented with signs and symptoms of impending adrenal crisis when referred for evaluation of large bilateral adrenal masses diagnosed on a computed tomography scan two weeks prior. Based on a high clinical suspicion of adrenal insufficiency, patient was initiated on glucocorticoid and mineralocorticoid therapy prior to laboratory confirmation of adrenal insufficiency. After stabilizing the patient and excluding pheochromocytoma, we proceeded with adrenal biopsy that revealed a nongerminal center-type diffuse large B-cell lymphoma. Our patient was treated with R-CHOP chemotherapy, with good response after 3 cycles but eventually died after the fifth cycle from neurologic complications. This case highlights the notion that primary adrenal insufficiency should be considered in patients presenting with bilateral adrenal masses. Although primary adrenal lymphoma is a very rare adrenal malignancy it should be considered in patients presenting with bilateral rapidly growing adrenal tumors and primary adrenal insufficiency. -
Case Report
Gluhovschi G, Velciov S, Lazar E, Potencz E, Puscasiu T, Trandafirescu V, Petrica L, Bozdog G, Gluhovschi C, Bob F, Gadalean F, Lazar D
Retroperitoneal fibrosis with favorable evolution under treatment with tamoxifenActa Endo (Buc) 2010 6(1): 95-102 doi: 10.4183/aeb.2010.95
AbstractRetroperitoneal fibrosis (RPF), a disease with a severe outcome due to the complications it causes, can be associated with the processes of atherosclerosis with a massive and extensive fibrosis. In this paper we present a patient with retroperitoneal fibrosis in which we noticed estrogen receptors at the level of the periaortic fibrous tissue\r\nand we obtained a regression of this process under treatment with tamoxifen. -
Case Report
Tasma H, Shalamar S
Giant Prolactinoma: an Unusual Case of Obstructive HydrocephalusActa Endo (Buc) 2011 7(1): 95-100 doi: 10.4183/aeb.2011.95
AbstractProlactinoma causing obstructive hydrocephalus is quite rare. We present a case of a 28-year-old previously healthy man who presented with sudden onset of dysarthria and expressive aphasia along with intense bifrontal headache and shortterm memory loss. Initial brain CT and brain MRI revealed a large 5.2 x 4.7 x 2.6 cm suprasellar mass, which extended to the third ventricle reaching up to the foramen of Monro and laterally displacing both internal carotid arteries. He was emergently placed an external ventricular drainage to relieve intracranial hypertension which led to immediate reversal of mental status as well as speech ability. His extensive endocrine work-up demonstrated a prolactin level with dilution of 12,650 µg/L (normal=2-18 µg/L) (549,996.7 pmol/L) consistent with the diagnosis of giant macroprolactinoma. Bromocriptine was initiated with successful tumor shrinkage and normalization of prolactin level within 7 months after initial presentation. Our case demonstrates the importance of obtaining a thorough hormonal evaluation of a large sellar lesion causing obstructive hydrocephalus to allow for an accurate diagnosis. It also demonstrates the effectiveness of medical therapy in the treatment of macroprolactinomas, even if very large. Medical treatment with dopamine agonists is still a first-line, effective approach with a favorable outcome in patients with giant macroprolactinomas causing intracranial hypertension and neurological symptoms as was the case in our patient. -
Case Report
Spiroiu C, Mazilu A, Jinga M, Mihai AM, Ranetti AE
Diagnostic difficulties in insulinomas. The importance of endoscopic ultrasonographyActa Endo (Buc) 2006 2(1): 95-107 doi: 10.4183/aeb.2006.95
AbstractInsulinoma is the most common endocrine tumor of the pancreas. The diagnosis suspicion is usually based on clinical symptoms and is confirmed by biochemical tests. Because the majority of insulinomas have a small size, the real problem is the localization of these tumors before surgery. We present the diagnostic and therapy difficulties, the value of available imaging techniques as well as our experience in five consecutive insulinoma patients from our clinic.