July - September 2010, Volume 6, Issue 3

Cimpean AM, Raica M, Coculescu M

SOX2 as a stem/progenitor cell-associated marker in pituitary prolactinoma

Acta Endo (Buc) 2010, 6 (3): 389-391
doi: 10.4183/aeb.2010.389

We highlight here in a human pituitary prolactinoma, by double immunohistochemistry, clusters of cells with strong reactivity for Sox2 and prolactin The colocalization was mainly distributed at the periphery of the tumor. In contrast, in the central part of the same tumor, only\r\nisolated cells expressed Sox 2 colocalised with prolactin. To the best of our knowledge, this is the first microscopic evidence of Sox2 positivity in prolactin secreting cells from human pituitary and from such type of human pituitary adenoma.

Keywords: Sox2, stem/progenitor cells markers, prolactinoma

Correspondence: M.Raica, ?Victor Babes? University of Medicine and Pharmacy - HIstology, Piata Eftimie Murgu 2 , Timisoara, Timis 300041, Romania, Email: raica@umft.ro