April - June 2013, Volume 9, Issue 2

Chang Z, Jian W

Duodenal Gangliocytic Paraganglioma. Case Report

Acta Endo (Buc) 2013, 9 (2): 315-318
doi: 10.4183/aeb.2013.315

Objective. To investigate clinicopathologic feature, diagnosis and differential diagnosis of gangliocytic paraganglioma (GP). Methods. Clinical data, histologic findings of one GP case in our hospital were reported and we reviewed the published literature on GP. Results. GP is composed of three types of cells: spindle cells, ganglion-like cells, and epithelioid cells. Several kinds of antibodies were used to evaluate and identify tumor cells immunohistochemically. Epithelioid cells showed positive results with antibodies for NSE , CgA, Syn, Ck and negative results with antibodies for S-100 protein, CD117.Spindle cells showed positive results with antibodies for S-100 protein, CD34 and negative results with antibodies for CD117, NSE, CgA, Syn, CK. Ganglion-like cells showed positive results with antibodies for NSE, CgA, Syn, CD117 and negative results with antibodies for S-100 protein and CK . In some cases, metastatic spread to regional lymph nodes or recurrence has been reported. Conclusions. GP is a rare true neuroendocrine tumor of potential metastatic capacity.

Keywords: gangliocytic paraganglioma, neuroendocrine tumor of potential metastatic capacity, spindle cells, ganglion-like cells, epithelioid cells, IHC.

Correspondence: Dr. Wu Jian, Department of Pathology, Huaian First People`s Hospital, Huaian, 223300, China, E-mail: wujian77@126.com