The International Journal of Romanian Society of Endocrinology / Registered in 1938

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Acta Endocrinologica(Bucharest) is live in PubMed Central

April - June 2020, Volume 16, Issue 2
Actualities in medicine

Burcea I, Poiana C

Updates in Aggressive Pituitary Tumors

Acta Endo (Buc) 2020, 16 (2): 267-273
doi: 10.4183/aeb.2020.267

Aggressive pituitary tumors lie between pituitary adenomas and carcinomas, displaying a particular behavior, with invasion, resistance to conventional therapy and early recurrence. The radiological grading, along with prognostic markers such as Ki-67 proliferation index, p53, MGMT and transcription factors are important factors in establishing the benign, aggressive, or malignant nature of pituitary tumors, with a more accurate treatment strategy. In this article, we report the novelties in defining, classifying, and managing aggressive pituitary tumors and their malignant potential, focusing on clinicopathological, histological, molecular and radiological data.

Keywords: pituitary, aggressive, immunohistochemistry, transcription factors.

Correspondence: Iulia Burcea MD, “C.I. Parhon” National Institute of Endocrinology, Pituitary and Neuroendocrinology, Aviatorilor 34-36, Bucharest, 011863, Romania, E-mail: