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Romanian Academy
The Publishing House of the Romanian Academy
ACTA ENDOCRINOLOGICA (BUC)
The International Journal of Romanian Society of Endocrinology / Registered in 1938in Web of Science Master Journal List
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Acta Endocrinologica (Buc)
Capatina C, Poiana C
Dopamine Agonists in the Management of Non-Functioning Pituitary Adenomas
Acta Endo (Buc) 2021, 17 (3): 377-382doi: 10.4183/aeb.2021.377
Non-functioning pituitary tumors (NFPA) are
usually large at the time of diagnosis and present with
symptoms caused by compression on the neighbouring
structures. Transsphenoidal resection of the tumor is the firstline
treatment but in many cases complete tumor resection
cannot be attained. Close follow-up with repeated hormonal
assessment and pituitary imaging is recommended after
surgery. During follow-up of the tumor remnant sometimes
radiotherapy is used to stop or prevent tumor progression.
Medical treatment with dopamine agonists (DA) is the
mainstay in the management of prolactinomas. For NFPA
several small series or case reports suggested beneficial
effects with tumor shrinkage in some cases. The aim of the
current paper is to summarize the available evidence related
to the potential efficacy of DA medical treatment in NFPA
while underlining that in the absence of randomized, placebocontrolled
studies, no final conclusion on the efficacy of these
drugs in the treatment of NFPA can be drawn.
Keywords: dopamine agonists, non-functioning,
pituitary, adenomas.
Correspondence: Cristina Capatina MD, “Carol Davila” University of Medicine and Pharmacy, Dept. of Endocrinology, 34-36
Aviatorilor blvd., Bucharest, 011863, Romania, E-mail: cristina.capatina@yahoo.com