The International Journal of Romanian Society of Endocrinology / Registered in 1938

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April - June 2022, Volume 18, Issue 2
General Endocrinology

Cocolos AM, Vladoiu S, Caragheorgheopol A, Ghemigian AM, Ioachim D, Poiana C

Vitamin D Level and its Relationship aith Cancer Stage in Patients with Differentiated Thyroid Carcinoma

Acta Endo (Buc) 2022, 18 (2): 168-173
doi: 10.4183/aeb.2022.168

Background. Differentiated thyroid carcinoma (DTC) has witnessed an increase in incidence and although it is considered to have a slow grow potential and a 90% 10- year survival rate, local or distant metastases can be observed in 20%. It is essential to recognize other factors associated with malignancy and poor prognosis. Vitamin D and its deficiency has proven useful as a prognostic biomarker for many types of cancer, including thyroid cancer. Aim. Evaluate the relationship between vitamin D status in DTC and benign thyroid disorders patients and correlation between vitamin D and histopathological findings in DTC group. Methods. Study included 170 patients with confirmed DTC and 200 with benign thyroid pathology. Evaluation included 25-hydroxy vitamin D [25(OH)D], ultrasound and histopathologic features. Results. In DTC patients, mean value of vitamin D was significantly lower (17.86 ng/mL ± 9.31 DS versus 20.26 ng/mL ± 9.31 DS, p=0.029). Statistical analysis confirmed a negative correlation between vitamin D levels and tumor size (T) according to TNM classification (r=-0.176, p=0.02). Conclusions. Vitamin D level was significantly lower in the DTC group and 25(OH)D levels may be correlated with histopathology features like tumor size and aggressiveness according to TNM classification.

Keywords: vitamin D, differentiated thyroid cancer, TNM, pappillary thyroid cancer.

Correspondence: Andra-Maria Cocolos MD, “C.I. Parhon” Institute of Endocrinology, 34-38 Aviatorilor blvd., Bucharest, 011863, Romania, E-mail: