October - December 2023, Volume 19, Issue 4

Liu G, Geng J, Jin R, Zhang N, Mei L

The Clinical Significance of Complete Blood Count, Neutrophil-Tolymphocyte Ratio, and Monocyte-To-Lymphocyte Ratio in Gestational Diabetes Mellitus

Acta Endo (Buc) 2023, 19 (4): 441-446
doi: 10.4183/aeb.2023.441

Background. To investigate the association between inflammatory factors, such as complete blood count (CBC) components, neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and gestational diabetes mellitus (GDM). Methods. A total of 635 pregnant women with GDM and 296 with normal pregnancies at 7–13 weeks of gestation who underwent prenatal examinations in the obstetrics department were enrolled (June 2020–December 2020). CBC parameters, including WBC, neutrophil, lymphocyte (LYM), monocyte (MON), red blood cell (RBC), hemoglobin (HGB), mean corpuscular volume (MCV), platelet (PLT), platelet accumulation (PCT), mean platelet volume (MPV), NLR, MLR, PLR, alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyl transferase (GGT), and other parameters were assessed. The receiver operating characteristic (ROC) curve was used to analyze the screening effects of the variables on the development of GDM. Results. There were significant differences in the blood levels of WBC, NEU, LYM, MON, RBC, HGB, PCT, ALT, AST, GGT, NLR, and MLR between the GDM and control groups (P<0.05). The diagnostic level of MON was the highest among all factors. Conclusion. Inflammatory factors (WBC, NEU, LYM, MON, NLR, and MLR counts) were correlated with GDM.

Keywords: Gestational diabetes mellitus, Leukocyte, Pregnancy, Monocyte/lymphocyte ratio, Neutrophil/lymphocyte ratio.

Correspondence: Ningzhi Zhang MD, Anhui Medical University, Obstetrical Department, Fu yang People's Hospital Affiliated to Anhui Medical University, Anhui FuYang, Hefei, 236000, China, E-mail: fyniyanghe@163.com