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ACTA ENDOCRINOLOGICA (BUC)
The International Journal of Romanian Society of Endocrinology / Registered in 1938in Web of Science Master Journal List
Acta Endocrinologica(Bucharest) is live in PubMed Central
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Notes & Comments
Voicu V, Medvedovici A, Miron D, Radulescu F
A novel approach on pharmacokinetic/pharmacodynamic correlations of risperidone: understanding its safety and efficacy profilesActa Endo (Buc) 2010 6(2): 265-285 doi: 10.4183/aeb.2010.265
AbstractThe pharmacokinetic characteristics of a compound as well as the immediate consequences of its physicochemical behavior during interactions with biological structures,\r\nrepresent the key issues for its pharmacodynamic profile, starting from the most fundamental global aspects (i.e. central and / or peripheral action) to the most detailed ones (i.e. molecular mechanism of action).\r\nSuccessive metabolic reactions lead to either bioactivation or bioinactivation of themolecular entity. A particular importance is currently assigned to several molecular\r\nphysicochemical descriptors, for instance the polarity degree (mirroring the changes of partition coefficients and of the permeability of biological structures), and emphasizing on distribution and renal excretion rate.\r\nThe active metabolite (9-hydroxy-risperidone) of the atypical antipsychotic agent risperidone has an increased polar character and, consequently, its pharmacokinetic profile is modified compared to the parent drug: especially the penetration through the bood brain barrier and the efflux pump mediated transport were considered. In this context, the kinetic characteristics and their correlation with the pharmacodynamic properties for the two active\r\nentities, as well as the consequences dealing with the antipsychotic efficacy, the safety and efficacy profiles can be anticipated. The present approach critically asseses the available data from literature corroborated with the personal findings over the last years. -
Images in Endocrinology
Radulescu V, Dumitrascu A, Alexandrescu D, Badiu C
Zoster Triggers in Graves OphthalmopathyActa Endo (Buc) 2023 19(2): 267-268 doi: 10.4183/aeb.2023.267
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General Endocrinology
Liu F, Duan JT, Teng X, Peng DQ
The Increased Plasma Levels of Intermedin in Patients with Type 2 Diabetes MellitusActa Endo (Buc) 2022 18(3): 271-277 doi: 10.4183/aeb.2022.271
AbstractContext. Intermedin (IMD) is the member of calcitonin gene-related peptide family, and tightly associated with type 2 diabetes mellitus (T2DM). The change of plasma IMD levels in T2DM is still unknown. Objective. We aimed to investigate the plasma levels of IMD in patients with T2DM. Design. Fortyone patients with T2DM who were hospitalized in the endocrinology department of Civil Aviation General Hospital from January 2012 to June 2015 were enrolled, and 44 volunteers were selected as the control group. Subjects and Methods. Plasma level of IMD was detected by ELISA. Diagnostic value of IMD was analyzed by area under the receiver operating characteristic (ROC) curve (AUC). Results. The plasma level of IMD in T2DM group was higher than that in the healthy control group, whereas smoking or cardiovascular complications did no influence the IMD levels. IMD levels were correlated with BMI, DBP, triglyceride, uric acid, urea nitrogen, fasting and 2 hours postprandial blood glucose, and HbA1C. The greatest value of AUC for IMD was only 58.73%. Conclusions. Although plasma levels of IMD were increased in patients with T2DM, the very low diagnostic value of IMD for T2DM might not be used for the disease diagnosis. -
General Endocrinology
Naumescu S, Georgescu C, Dragatoiu G, Hazi G, Duncea I, Gozariu L
Studies concerning the correlation between leptin and body compositionActa Endo (Buc) 2005 1(3): 271-280 doi: 10.4183/aeb.2005.271
Abstract ReferencesIntroduction: Leptin, which is known to regulate appetite and energy expenditures, may also contribute to mediate the effects of fat mass on the bone.\r\nObjective: The aim of this study was to analyse to what extent leptin and total body composition influence the maintenance of bone mass.\r\nSubjects and methods: We evaluated 34 women divided into two BMI-matched groups based on the ovarian function: 12 premenopausal women, aged 34.08?7.18 years and 22 postmenopausal women aged 61.31?4.51 years, respectively. Total body composition (total fat mass, trunk fat mass and lean mass) and bone mineral density were measured by means of dual-energy X-ray absorptiometry (DXA). Serum leptin concentrations were assessed by ELISA.\r\nResults: The bone mineral content was influenced by both the fat mass (women with normal menstrual cycles r=0.62, p=0.03; postmenopausal women r=0.625, p=0.002) and the trunk fat mass (r=0.597, p=0.004 premenopausal women; r=0.675, p=0.001 postmenopausal women), independently of the ovarian function. Only for the postmenopausal group we could identify a significant correlation between leptin levels and the total body bone mineral density (r=0.479, p=0.024) and the total body bone mineral content (r=0.605, p=0.003), respectively. The serum leptin levels were highly significantly correlated with the total fat mass and the trunk fat mass for both groups. No difference was obtained with regard to the serum leptin levels between pre- and postmenopausal women.\r\nConclusions: Our results suggest the role played by leptin and the fat mass in the maintenance of bone mass.1. Ricci TA, Heymsfield SB, Pierson RN Jr, Stahl T, Chowdhury HA, Shapses SA. Moderate energy restriction increases bone resorption in obese postmenopausal women. Am J Clin. Nutr. 2001; 73(2): 347-352.2. Elefteroiu F, Karsenty G. Bone mass regulation by leptin: a hypothalamic control of bone formation. Pathol Biol. 2004; 52(3): 148-153.3. Jones KB, Mollano AV, Morcuende JA, Cooper RR, Saltzman CL. Bone and brain: a review of neural, hormonal and musculoskeletal connections. Iowa Orthop J. 2004; 24: 123-132.4. Takeda S. Leptin and beta-blockers in bone metabolism. Clin Calcium. 2004; 14(2): 241-247.5. Thomas T. Leptin: a potential mediator for protective effects of fat mass on bone tissue. Joint Bone Spine. 2003; 70(1): 18-21.6. Takeda S, Karsenty G. Central control of bone formation. J Bone Miner Metab. 2001; 19(3): 195- 198.7. Karsenty G. Leptin controls bone formation through a hypothalamic relay. Recent Prog Horm Res. 2001; 56: 401-415.8. Ducy P, Schinke T, Karsenty G. The osteoblast: a sophisticated fibroblast under central surveillance. Science. 2000; 289: 1501-1504.9. Cock TA, Auwerx J. Leptin: cutting the fat off the bone. Lancet. 2003; 362: 1572-1574. [CrossRef]10. Whitfield JF. How to grow bone to treat osteoporosis and mend fractures. Curr Rheumatol Rep. 2003; 5(1): 45-56. [CrossRef]11. Marie P, Debiais F, Cohen Solal M, de Vernejoul MC. New factors controlling bone remodeling. Joint Bone Spine. 2000; 67(3): 150-156.12. Grigorie D, Neacsu E, Marinescu M, Popa O. Circulating osteoprotegerin and leptin levels in postmenopausal women with and without osteoporosis. Rom J Intern Med. 2003; 41(4): 409-415.13. Javaid, Godfrey, Taylor et al. Umbilical cord leptin predicts neonatal bone mass. Calcif Tissue Int. 2005; 76(5): 341-347. [CrossRef]14. Yamauchi M, Sugimoto T, Yamaguchi T. et al. Plasma leptin concentrations are associated with bone mineral density and the presence of vertebral fractures in postmenopausal women. Clin Endocrinol. 2001; 55(3): 341-347.15. Dennison EM, Syddall HE, Fall CH et al. Plasma leptin concentration and change in bone density among elderly men and women: the Hertfordshire cohort Study. Calcif Tissue Int 2004; 74(5): 401- 406.16. Ruhl CE, Everhart JE. Relationship of serum leptin concentrations with bone mineral density in the United States population. J Bone Miner Res. 2002; 17(10): 1896-1903.17. Odabasi E, Ozata M, Turan M. et al. Plasma leptin concentrations in postmenopausal women with osteoporosis. Eur J Endocrinol 2000; 142(2): 170-173.18. Sahin G, Polat G, Baethis S et al. Body composition, body mineral density, and circulating leptin levels in postmenopausal Turkish women. Rheumatol Int. 2003; 23(2): 87-91.19. Hadji P, Bock K, Gotschalk M et al. The influence of serum leptin concentration on bone mass assessed by quantitative ultrasonometry in pre and postmenopausal women. Maturitas. 2003; 44(2): 141-148.20. Shaarawy M, Abassi AF, Hassan H, Salem ME. Relationship between serum leptin concentrations and bone mineral density as well as biochemical markers of bone turnover in women with postmenopausal osteoporosis. Fertil Steril. 2003; 79(4): 919-924.21. Roux C, Arabi A, Porcher R, Garnero P. Serum leptin as a determinant of bone resorption in healthy postmenopausal women. Bone. 2003; 33(5): 847-852.22. Reid IR. Relationships among body mass, its components, and bone. Bone. 2002; 31(5): 547-555. -
Images in Endocrinology
Pop LG, Radulescu M, Toader OD, Suciu ID
Fetal Neuroblastoma. Ultrasound and MRI FindingsActa Endo (Buc) 2019 15(2): 272-273 doi: 10.4183/aeb.2019.272
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General Endocrinology
Capusa C, Chirculescu B, Vladu I, Viasu L, Lipan M, Mota E, , Mircescu G
The Prevalence of Biochemical Abnormalities of Chronic Kidney Disease. Mineral and Bone Disorders in Untreated Non-dialysis Patients – A Multicenter StudyActa Endo (Buc) 2016 12(3): 282-290 doi: 10.4183/aeb.2016.282
AbstractBackground. There are scarce data about prevalence of mineral metabolism (MM) disorders in Romanian predialysis patients, so we assessed their occurrence and relationships in mild to severe chronic kidney disease (CKD). Methods. One hundred fifteen non-dialysis CKD (eGFR 31, 95% CI 29-35mL/min) and 33 matched non-CKD subjects entered this multicentric, cross-sectional study. Serum 25-hydroxyvitamin D (25OHD), intact parathyroid hormone (iPTH), phosphate (PO4), total calcium (tCa) and alkaline phosphatase (AP) were measured, along with demographic and past medical history data. Results. Hypovitaminosis D was equally prevalent in Controls and CKD (91% vs. 96% had 25OHD<30ng/mL). Increasing proportions of hyperparathyroidism (33% - stage 2 to 100% - stage 5; p<0.001) and hyperphosphatemia (2% - stage 3 to 38% - stage 5; p<0.001) were found. Hypocalcemia was more prevalent in stage 5 (25% vs. 6% in stage 4, none in stage 3 and Controls, p<0.001). Mineral metabolism parameters correlated with eGFR. In addition, iPTH was directly associated with PO4, AP, and urinary albumin-tocreatinine ratio (ACR), but inversely with tCa and 25OHD, while negative correlation of 25OHD with age, AP, ACR, and C-reactive protein emerged. In multiple regression, eGFR was the only predictor of iPTH (Beta -0.68, 95%CI -1.35 to -0.90, R2 0.46, p<0.001), whereas age and ACR were the determinants of 25OHD (a model which explained 14% of its variation). Conclusions. Hypovitaminosis D was very common irrespective of CKD presence and severity, and it seems worsened by older age and higher albuminuria. Hyperparathyroidism preceded hyperphosphatemia and hypocalcemia, and it seems mostly dependent on kidney function decline -
General Endocrinology
Cakmak Genc G, Karakas Celik S, Arpaci D, Aktas T, Can M, Bayraktaroglu T, Dursun A
Granulysin Peptide and Gene Polymorphism in the Pathogenesis of Hashimoto ThyroiditisActa Endo (Buc) 2022 18(3): 288-293 doi: 10.4183/aeb.2022/288
AbstractBackground. Hashimoto thyroiditis (HT) is an autoimmune disease and the most common cause of hypothyroidism. The widespread lymphocyte infiltration in the thyroid gland and intolerance of the body against its thyroid antigens leads to the destruction of thyroid cells and impaired thyroid function. Granulysin (GNLY) is a cytolytic antimicrobial peptide that has been associated with a wide range of diseases such as various infections, cancer, transplantation, and skin problems. However, there are a few studies investigating the relationship between HT and granulysin. Aim. Our study aims to investigate whether granulysin levels and GNLY gene polymorphism contribute to the damaged immune response leading to HT. Material and Methods. 100 unrelated patients diagnosed with HT and 140 healthy individuals were included in our study. Frequencies of GNLY rs10180391 and rs7908 gene polymorphisms were determined using PCR- RFLP method and serum granulysin levels were determined using ELISA. Results. There is no statistical significance between patient and control groups in terms of genotype and allele frequencies of GNLY gene polymorphisms and serum levels of granulysin. Conclusion. In conclusion, granulysin and GNLY gene polymorphisms do not appear to relate to HT disease. -
Images in Endocrinology
Gheorghiu ML, Dumitrascu A, Chirita C
Hyperparathyroidism during Chronic HemodialysisActa Endo (Buc) 2011 7(2): 291-291 doi: 10.4183/aeb.2011.291
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General Endocrinology
Vata L, DumitriuI, Gurzu M, Slatineanu S, Vata A, Gurzu B
Ghrelin effects on local renin angiotensin from pulmonary vesselsActa Endo (Buc) 2010 6(3): 295-304 doi: 10.4183/aeb.2010.295
AbstractBackground: Published data sustain the participation of vascular renin angiotensin system (RAS) on alteration of pulmonary vessels reactivity during the allergic airway inflammation. Ghrelin is a growth hormone-releasing peptide involved in modulation of immune function.\r\nObjective: This study aims to investigate the interaction between ghrelin and local RAS from rat pulmonary vessels during ovalbumin ? induced allergic airway disease. Methods: The angiotensinogen (AGT) ? induced contractions were assessed on isolated pulmonary artery and veins from ovalbumin sensitized rats receiving either saline (OSR) or ghrelin (OSG) by endotracheal instillation. Experiments were performed in the absence or the presence of losartan, D-ALA7, chymostatin and Nω-nitro-L-arginine methyl ester (L-NAME).\r\nResults: The AGT contractile effects mediated by AT1 receptors were lower with at least 25% on vessels from OSG than from OSR. The D-ALA7 and L-NAME significantly increases the AGT ? induced contraction on OSG. The amount of nitric oxide released after stimulation with AGT is higher on OSG and it is blocked by D-ALA7.\r\nConclusion: Our results suggested that pulmonary delivery of ghrelin could modulate the local RAS from pulmonary vessels by promoted the angiotensin 1-7 mediated effects. These data sustained the existence of another possible way for ghrelin?s beneficial effects on the lung. -
Endocrine Care
Georgescu C, Ilie I, Paul A, Mihu D, Duncea I, Mocanu T, Duncea I
Value of quantitative heel and proximal phalanges ultrasonography versus dual X-ray absorptiometry in women aged 24-80 yearsActa Endo (Buc) 2008 4(3): 297-308 doi: 10.4183/aeb.2008.297
AbstractDespite several attempts to establish the role of QUS in clinical practice, issues such as definition of osteoporosis based on QUS, screening strategy and therapy efficacy for patients identified by QUS as having high risk of fracture remain a matter of debate. The present study aimed to evaluate the diagnostic agreement between two QUS techniques (heel QUS and proximal phalanges QUS) and DXA in an unselected population of Romanian women aged 24- 80 years, as well as to offer cut-off levels for QUS to distinct between women with or without osteoporosis identified by DXA. In women measured by both DXA and calcaneus QUS (c- QUS), bone mineral density (BMD) moderately correlated with stiffness index (SI) (L1-L4: r=+0.51, p<0.001; femoral neck: r=+0.53, p<0.001; hip: r=+0.57, p<0.001), while in women examined by both DXA and phalanx QUS (ph-QUS), BMD was positively related to amplitude-dependent speed of sound (Ad-SoS) (L1-L4: r=+0.47, p<0.001; femoral neck: r=+0.50, p<0.001; hip: r=+0.38, p<0.001) and ultrasound bone profile index (UBPI) (L1-L4: r=+0.44, p<0.001; femoral neck: r=+0.50, p<0.001; hip: r=+0.38, p<0.001). At a T-score cutoff level of -2.5SD, the high specificity but low sensitivity suggests a low false positive rate of c-QUS as a diagnostic test; still, several patients with the disease may not be correctly diagnosed. At the same cut-off level, ph-QUS showed higher sensitivity and lower specificity. Diagnostic agreement between DXA and QUS was poor, with k-scores ranging from 0.33 to 0.39 for c-QUS and from 0.14 to 0.29 for ph-QUS, respectively. Lowering c-QUS T-score cutoff for lumbar spine osteoporosis screening to -1.5SD and ph-QUS T-score cut-off to -1.9SD, respectively, improved sensitivity and had a minor effect on diagnostic agreement. Regardless of the evaluated site, neither c-QUS nor ph-QUS does represent an adequate predictor of BMD in Romanian women. Changing the diagnostic T-score threshold from -2.5 SD to -1.5 SD and -1.9 SD in subjects examined by c-QUS or ph-QUS, respectively, is followed by improved sensitivity and diagnostic agreement in the identification of patients with vertebral osteoporosis. Cut-off values may allow QUS to be used as a screening tool for spine and femur osteoporosis.