April - June 2010, Volume 6, Issue 2

Ustun I, Aydin Y, Ary Arduc A, Berker D, Ozuguz U, Yylmaz M, Erden G, Unlu E

Evaluation of atherosclerotic risk factors and carotid intima media thickness in healthy offspring of type 2 diabetic patients

Acta Endo (Buc) 2010, 6 (2): 211-227
doi: 10.4183/aeb.2010.211

Aim is to evaluate atherosclerotic risk factors and carotid intima media thickness [CIMT] in offspring of type 2 Diabetes Mellitus [DM] patients with normal glucose tolerance. Methods. We evaluated 96 offspring of Type 2 DM patients and 39 healthy control who were in similar age, sex and body mass. We measured fasting blood glucose [FBG], postprandial blood glucose [PBG], insulin, uric acid, homocystein, fibrinogen, HOMA-IR, lipid profile, hsCRP, microalbuminuria, glycosylated hemoglobin A1c and CIMT by Doppler ultrasonography. Results. FBG was found higher in study group [p<0.001]. The HOMA-IR was 1.7±0.98 and 1.2±0.58 mg/dL x uUI/mL for study and control group, respectively [p=0.007]. TCholesterol, triglycerides, HDL-C, LDL-C and homocystein levels were not different. HsCRP and fibrinogen levels were higher in study group [p=0.014 and p=0.035, respectively]. Microalbuminuria levels were higher in study group but not significant [p=0.111]. CIMT in study group increased distinctively [p<0,001]. In regression analysis, being in study group causes a significant increase on the mean CIMT level by 0.057 mm [0.029-0.086] Conclusion. Our study demonstrated that various atherosclerotic risk factors are aggregated in offspring of Type 2 DM patients having NGT even before they develop glucose intolerance. Having a diabetic family alone might be effective in developing increased CIMT.

Keywords: Atherosclerosis, carotid intima media thickness, offspring, diabetes mellitus

Correspondence: Ihsan Ustun, Mustafa Kemal University - Endocrinology and Metabolism, Mustafa Kemal Universitesi Tayfur Sökmen Tip Fakültesi Serinyol/Hatay/Antakya Antakya hatay 31120, Turkey; E-mail: iustun@yahoo.com, ihsanustun@hotmail.com