The International Journal of Romanian Society of Endocrinology / Registered in 1938

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January - March 2023, Volume 19, Issue 1
Case Series

Yazan CD, Yavuz DG

Efficacy of Double Filtration Plasmapheresis Treatment in Acute Pancreatitis Associated with Severe Hypertriglyceridemia

Acta Endo (Buc) 2023, 19 (1): 125-130
doi: 10.4183/aeb.2023.125

Background and aim. Hypertriglyceridemia is one of the leading causes of acute pancreatitis and is associated with increased morbidity and mortality. Today the recommended treatment options are fasting, hydration, if necessary antibiotics and there is not a standard recommendation to decrease triglycerides rapidly. Double Fıltratıon Plasmapheresis (DFPP) may be an option to decrease triglycerides rapidly but its effect on the disease course is unknown. Method. In the present study, we present results of four acute pancreatitis cases associated with hypertriglyceridemia treated with DFPP. All of the patients were diagnosed as acute pancreatitis at emergency room and no complications were observed in sessions. A 76.3% reduction in triglyceride levels was observed in one or two treatment sessions. Results and conclusion. DFPP is an effective and safe option to decrease triglyceride levels rapidly but further research is needed to show the effect on mortality and morbidity.

Keywords: severe hypertriglyceridemia, plasmapheresis, pancreatitis.

Correspondence: Ceyda Dincer Yazan MD, Marmara University, School of Medicine, Endocrinology and Metabolism, Marmara University, Pendik Training and Research Hospital, Istanbul, 34668, Turkey, E-mail: