ACTA ENDOCRINOLOGICA (BUC)

The International Journal of Romanian Society of Endocrinology / Registered in 1938

in Web of Science Master Journal List

Acta Endocrinologica(Bucharest) is live in PubMed Central

Journal Impact Factor - click here.

Year Volume Issue First page
10.4183/aeb.
Author
Title
Abstract/Title
From through

  • Images in Endocrinology

    Yu J, Qin C, Huang S, Ye X, Meng N

    Treatment of Giant Juvenile Breast Fibroadenoma by Single Hole Breast Endoscopy: a Case Report

    Acta Endo (Buc) 2021 17(4): 552-553 doi: 10.4183/aeb.2021.552

  • Notes & Comments

    Uyaroglu OA

    An Interesting Experience with Empagliflozin: Unidentified Body Odor

    Acta Endo (Buc) 2021 17(4): 554-556 doi: 10.4183/aeb.2021.554

    Abstract
    Context. Sodium-glucose co-transporter 2 inhibitors (SGLT2-I) are a new class of oral antidiabetic drugs. Objective. Side effects of drugs are frequently encountered with increasing use in clinical practice. Design/Subjects and Methods. We present a case with an unidentified body odor that has not been described yet in the literature as an adverse effect of SGLT2-I. Results. A 49-year-old female patient with Type 2 DM was applied to our clinic for routine control. She had been receiving sitagliptin/metformin 50/1000 mg b.i.d. Her fasting plasma glucose was 160 mg/dL and HbA1c was 8%. Empagliflozin 10 mg/day was added to therapy. The patient noticed that two weeks after starting empagliflozin treatment, she began to smell herself and felt a bad/foul odor was released from her body. The patient associated these complaints with the new drug(empagliflozin) stopped two weeks ago. She also stated that all these complaints had disappeared one week after stopping the medication and there were no complaints at the moment. Conclusions. Here we report an unidentified body odor as a potential empagliflozin-associated adverse event. There was a close temporal relationship between empagliflozin intake and the development and the occurrence of the described odor.
  • Letter to the Editor

    Mihali CV, Petrescu CM, Ladasiu-Ciolacu FC, Mândrutiu I, Bechet D, Nistor T, Ardelean A, Benga G

    Plasma Phenylalanine Determination By Quantitative Densitometry of Thin Layer Chromatograms and by High Performance Liquid Chromatography in Relation with Modern Management of Phenylketonuria

    Acta Endo (Buc) 2018 14(4): 556-561 doi: 10.4183/aeb.2018.556

    Abstract
    Background. The modern management of phenylketonuria (PKU) consists of generalized newborn screening (NBS) for hyperphenylalaninemia (HPA), confirmation of HPA in children detected in the NBS, introduction of dietary treatment in the first weeks of life, followed by monitoring the treatment of PKU for decades to maintain phenylalaninemia within the limits that will not affect the brain. The present study aimed to evaluate the usefulness of two chromatographic methodologies for determination of plasma Phe level in the routine management of PKU: the two dimensional thin layer chromatography (2D - TLC) and the high performance liquid chromatography (HPLC) procedures, respectively. Material and Methods. Samples of blood from 23 children with HPA detected by neonatal screening or with confirmed PKU who received treatment by low-Phe diet were analyzed to estimate the plasma Phe level by the two chromatographic procedures. Results. In case of three subjects the very low concentrations of plasma Phe could not be detected by the 2D - TLC methodology, since the spot was not visible on the chromatogram. In four patients the differences between the values of plasma Phe determined by the two methodologies are not statistically significant, while in fifteen subjects the differences are highly statistically significant. This is due to the greater errors that appear in the case of 2D - TLC methodology. In the range of concentrations of plasma Phe higher than 360 μmol/L (which is the cut-off value for HPA), although in four cases there were statistically significant differences in the level of plasma Phe determined by the two methodologies, the value obtained by the 2D - TLC methodology was high enough to influence the decision of changing the diet so that HPA is kept under control. In addition, the intense spot of Phe on the 2D - TLC chromatogram may be detected even by un unexperienced laboratory specialist. Conclusion. The HPLC procedure for measurement of plasma Phe level is very suitable to be used in the routine management of PKU. The 2D - TLC procedure may be accompanied by relatively high errors; however, it detects patients with severe PKU.
  • Actualities in medicine

    Godoroja–Diarto D, Moldovan C, Tomulescu V

    Actualities in the Anaesthetic Management of Pheochromocytoma / Paraganglioma

    Acta Endo (Buc) 2021 17(4): 557-564 doi: 10.4183/aeb.2021.557

    Abstract
    The anaesthetic management of pheochromocytoma is complicated and challenging. However, preoperative pharmacologic preparation, modern anaesthetic techniques and drugs associated with advanced monitoring in conjunction with the evolution of surgical techniques (open laparotomy to laparoscopic surgery and robotic approaches in the present day) improved significantly perioperative outcome, and intraoperative and postoperative hemodynamic stability. Although there are not randomised clinical trials to suggest one approach over another and there is a high international variability amongst intraoperative anaesthetic techniques, most management principles are still universal.
  • General Endocrinology

    Gu PY, Kang DM, Wang WD, Chen Y, Zhao ZH, Zheng H, Ye SD

    Serum Oteocalcin Level is Independently Associated with the Carotid Intima-Media Thickness in Men with Type 2 Diabetes Mellitus

    Acta Endo (Buc) 2014 10(4): 559-569 doi: 10.4183/aeb.2014.559

    Abstract
    The role of osteocalcin in atherogenesis is unclear. We investigated the association between osteocalcin and carotid atherosclerosis in Chinese middle-aged and elderly male adults and further determined whether osteocalcin is independently associated with the carotid intima-media thickness (CIMT) in hyperglycemia subgroups. Subjects and methods. A total of 84 male participants (mean age, 59.13 years) were enrolled in groups of normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM) according to the oral glucose tolerance test. A standard interview, anthropometric measurements and laboratory analyses were performed for each participant. Bilateral carotid intima–media thicknesses (CIMT) were measured using ultrasonography. The circulating osteocalcin was measured using quantitative enzyme immunoassay. Results. Both IGT and newly diagnosed T2DM groups had significantly lower osteocalcin levels compared with the NGT group (5.01 ± 0.68 μg/L, and 6.173 ± 0.68 ng/mL vs. 11.55 ± 0.57 μg/L, respectively). Multivariate linear stepwise regression analysis demonstrated that waisthip ratio(WHR) (standardized β = -0.408, P = 0.000), 2 hour plasma glucose after glucose load, (PPG) (standardized β = -0.235, P = 0.025), homeostasis model of assessment for insulin resistance index(HOMA-IR) (standardized β = -0.287, P = 0.004), and Glycosylated haemoglobin (HbA1c) (standardized β = -0.250, P = 0.015) were independently and inversely associated with serum osteocalcin in hyperglycemia subgroups; PPG(standardized β = -0.476, P = 0.015), osteocalcin(standardized β = -0.486, P = 0.001) were negatively associated with CIMT, while TG (standardized β = 0.647, P = 0.000) was positively associated with CIMT in T2DM. Conclusion. These results showed that osteocalcin is independently associated with carotid atherosclerosis in men with T2DM. It is tempting to suggest that osteocalcin may be implicated atherosclerosis.
  • Case Report

    Koroglu BK, Aksu O, Ersoy IH, Ciris IM, Ermis F, Tamer MN

    Incidental Thyroid Papillary Microcarcinoma in a Patient with Graves' Ophthalmopathy

    Acta Endo (Buc) 2011 7(4): 561-564 doi: 10.4183/aeb.2011.561

    Abstract
    Thyroid carcinomas associated with Graves? ophthalmopathy had been described in the literature, before. The rate of this coincidence is 1.1% - 7.1%. Papillary carcinoma is more common than thyroid cancer in Graves? disease. Herein, we present a 37-year-old male Graves? disease patient with thyroid papillary carcinoma.
  • Book Review

    Niculescu DA

    Guidelines for diagnosis in endocrine pathology

    Acta Endo (Buc) 2009 5(4): 561-561 doi: 10.4183/aeb.2009.561

  • Book Review

    Baculescu N

    Yen and Jaffe's Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management

    Acta Endo (Buc) 2009 5(4): 562-562 doi: 10.4183/aeb.2009.562

  • Images in Endocrinology

    Danila OO, Hortopan D, Sucaliuc A, , Badiu C

    Euthyroid Exophthalmia in a Patient with Chronic Rhinosinusitis

    Acta Endo (Buc) 2018 14(4): 562-562 doi: 10.4183/aeb.2018.562

  • Notes & Comments

    Eizadi M, Laleh B, Khorshidi D

    The Effect of Aerobic Training with Difference Durations on Serum Il-10 in Middle-Aged Obese Females

    Acta Endo (Buc) 2018 14(4): 563-569 doi: 10.4183/aeb.2018.563

    Abstract
    Context. Regular training program is recognized to play a key role in chronic low-grade inflammation in obese patients. Objective. The aim of this study was to evaluate the effects of a continued aerobic training on serum Interleukine-10 (IL-10) as anti-inflammatory cytokine in obese women. Subjects and Methods. Thirty non-trained obese women aged 30-40 years with BMI 30-36 (kg/m2) participated in the study and divided into exercise (n=15) and control groups. Exercise subjects completed a 6 weeks aerobic training at 60-75% of heart rate max and continued to 12 weeks. Anthropometrical markers and fasting blood samples were collected of all subjects at pre, mid (6 weeks) and post training (12 weeks) for measuring serum IL-10. Data were analyzed using repeated measures ANOVA. Significance was accepted at P<0.05. Results. At baseline (pre training), there were no differences in the age, body weight and other anthropometrical indexes also in serum IL-10 between the two groups (p>0.05). Six and 12 weeks of aerobic training resulted in a significant decrease in body weight and other anthropometrical indexes and a significant increase in IL-10 compared to baseline (p<0.05). No significant difference was observed in serum IL-10 between 6 and 12 weeks aerobic training (p=0.361). There were no changes in all variables in the Control group (p>0.05). Conclusion. Based on this data we concluded that anti-inflammatory effects of long term aerobic training can be attributed in part to IL-10 but further studies over other markers of inflammatory profile are necessary in order to sustain the anti-inflammatory effect of aerobic training.