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ACTA ENDOCRINOLOGICA (BUC)
The International Journal of Romanian Society of Endocrinology / Registered in 1938in Web of Science Master Journal List
Acta Endocrinologica(Bucharest) is live in PubMed Central
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Case Report
Ozcabi B, Kirmizibekmez H, Yesiltepe Mutlu G, Dursun F, Guran T
Management of Rapidly Progressive Precocious Puberty in a Patient with Mosaic Turner SyndromeActa Endo (Buc) 2021 17(1): 101-105 doi: 10.4183/aeb.2021.101
AbstractContext. Rapidly progressive precocious puberty (RPPP) is a rare condition in Turner syndrome (TS), with no consensus on treatment and follow-up. Only 12 cases have been reported so far. Objective. We aimed to evaluate the effects of the GnRH analog (GnRHa) on growth and anti-mullerian hormone (AMH) levels in TS and RPPP. Design. The clinical and laboratory data was recorded at baseline and after treatment. Subjects and methods. An 8.1-year old girl with a karyotype of 45, X/46, XX presented with breast development at Tanner stage-2. Breast development advanced to Tanner stage-3 at the age of 8.7 years. Growth velocity (GV) was 8 cm/year. Bone age was 11 years with a predicted adult height of 152 cm. Luteinizing hormone (LH) was 1.69mIU/mL and estradiol was 33pg/mL, confirming the central puberty. AMH level was 6.33ng/mL. The sizes of ovaries and uterus were compatible with the pubertal stage, with an endometrial thickness of 5 mm. GnRHa was started for RPPP. Results. After three months, GV declined to 0 cm/3 months and AMH level to 50% of the baseline. Growth hormone (GH) treatment was started for insufficient growth. GV improved with GH treatment, as well as a far more decreased AMH level. Conclusion. GV usually declines before puberty in patients with TS, even if the mid-parental height is tall. RPPP should be considered if GV is increased. Excessive suppression of growth may be prevented with GH treatment. GnRHa treatment also plays a role in reducing AMH levels in patients with TS. -
Case Report
Maman A, Gultekin S
Vertebral GA-68 Dotatate Uptake Mimicking Lung Neuroendocrine Tumor MetastasisActa Endo (Buc) 2023 19(1): 104-107 doi: 10.4183/aeb.2023.104
AbstractA 57 years old woman was diagnosed with welldifferentiated lung neuroendocrine tumor (NET) by laboratory assessment, computed tomography (CT), contrast-enhanced magnetic resonance imaging (MRI) and bronchoscophy with transbroncial biopsy of nodular lung lesion located in the right lower lobe. Staging Ga-68 positron emission tomography-CT (PET-CT) showed two pathological uptake regions in the superior segment of the right lung lower lobe (SUVmax: 80.61) and 6th thoracic vertebral body (SUVmax: 3.70). Contrast-enhanced MRI findings suggested that vertebral lesion may be compatible with atypical hemangioma or osseous metastasis due to T1 isointensity, T2 hyperintensity and contrast-enhancement on the lesion. Therefore, characteristic imaging findings of hemangioma were seen on axial and sagittal or coronal sections of CT, respectively called as ‘polka dot’ and ‘corduroy cloth’. Thus the mild vertebral Ga-68 DOTATATE uptake was accepted as false positive finding. Surgical intervention was decided. She underwent a right lung lobectomy. The last follow-up of the patient was done 2 years after the initial diagnosis. The follow-up Ga-68 DOTATATE PET-CT revealed no pathological increased uptake in the whole-body except the 6th vertebra showing similar uptake (SUVmax: 3.50) with the previous scan without size increase on CT. The patient was asymptomatic with normal serum chromogranin A level. -
Case Report
Turgut E, Taner Z, Bayram M, Karcaaltincaba D
Successful Pregnancy Outcome in Patient with Niemann-Pick Disease Type B and Review of the LiteratureActa Endo (Buc) 2023 19(1): 108-111 doi: 10.4183/aeb.2023.108
AbstractNiemann-Pick disease (NPD), is a rare autosomal recessive lysosomal storage disorder. Niemann-Pick A and B are caused by homozygous or compound heterozygous mutations in the sphingomyelin phosphodiesterase-1 (SMPD1) gene on chromosome 11p15. Type B is panethnic, although its frequency is increased in Turkish, Arabic and North African populations. Clinical features vary significantly among patients. It is a rare condition and information about its management an outcome during pregnancy and labor is limited. Both maternal mortality and morbidity due to severe postpartum hemorrhage has been reported. We represent a case of successful pregnancy outcome in patient with NPD type B. Type of mutations in SMPD 1 gene and severity of disease before pregnancy can predict the prognosis of pregnancy. -
Case Report
Yalin GY, Dogansen SC, Canbaz B, Gul N, Bilgic B, Uzum AK
Incidental Paget’s Disease Disguised as Bone Metastasis in a Patient with Endometrium CarcinomaActa Endo (Buc) 2017 13(1): 111-114 doi: 10.4183/aeb.2017.111
AbstractPaget’s disease is a disorder of aging bone which occurs in the setting of accelarated bone remodelling. In the presented case we discuss the difficulties in the diagnosis of Paget’s disease in a 77 year old patient with coexisting endometrium carcinoma. The patient was initially diagnosed with metastatic bone disease due to endometrium adenocarcinoma when she was admitted to oncology clinic with pelvic pain. Bone scintigraphy with Tc99 and (18) F fluorodeoxyglucose positron emission tomography/CT revealed an increased uptake on the bone lesions which were reported as metastatic bone involvement. Although the (18) F-FDG uptake was much higher than the levels that would generally be anticipated in a case with Paget’s disease, high levels of bone turnover markers indicated further evaluation in the differential diagnosis and the definitive diagnosis of Paget’s disease was established with the pathological evaluation of bone biopsy. -
Case Report
Piskinpasa H, Ciftci Dogansen S, Kusku Cabuk F, Guzey D, Sahbaz NA, Akdeniz YS, Mert M
Bilateral Adrenal and Testicular Mass in a Patient with Congenital Adrenal HyperplasiaActa Endo (Buc) 2019 15(1): 113-117 doi: 10.4183/aeb.2019.113
AbstractIntroduction. Congenital adrenal hyperplasia (CAH) autosomal recessive disorders characterized by impaired adrenal steroid hormone synthesis. The most common form is 21-hydroxylase deficiency (21OHD). Testicular adrenal rest tumors (TARTs) are benign intratesticular masses that occur in male patients with CAH. TARTs are quite common in patients with 21OHD who were diagnosed late. Case report. A 41-year-old male patient with CAH secondary to 21OHD. The patient was referred to our endocrinology department from the andrology clinic for bilateral adrenal masses. Bilateral orchiectomy had been performed due to bilateral testicular masses and azoospermia two years ago. The pathology was reported as Leydig cell tumor. In hormonal assessment, baseline cortisol levels were low, 17-hydroxyprogesterone levels with baseline and after cosyntropin stimulation test were high. As a result of clinic and laboratory assessment, the patient was diagnosed with simple virilising CAH due to 21OHD and adrenal insufficiency. Then, prednisolone replacement was initiated. Bilateral orchiectomy tissue blocks of the patient were reassessed and were considered TART. Magnetic resonance imaging revealed bilateral adrenal masses with 88x55 mm on the right and 41x22 mm on the left. Laparoscopic right adrenalectomy was applied and pathology was reported as myelolipoma. Follow-up of the mass on the left adrenal gland is ongoing. The patient is monitored under prednisolone and testosterone replacement therapy. Early diagnosis of CAH is very important because of the complications it causes. It should be considered especially for bilateral testicular and/ or adrenal masses. Both fertility and adrenal glands can be protected with an early diagnosis and an early glucocorticoid replacement. -
Perspectives
Dede BT, Oguz M, Alyanak B, Bagcier F
Analysis of Public Interest about Osteoporosis Using Google Trends: Are Season and Economy Effective?Acta Endo (Buc) 2024 20(2): 121-126 doi: 10.4183/aeb.2024.121
AbstractBackground. The aim of this study was to assess the awareness of the USA and world population about osteoporosis, taking into account seasonal variations and economic conditions. Methods. The term “osteoporosis” was searched using Google Trends between January 1, 2004 and September 12, 2024. Cosinor analysis was used to test the effect of seasonality on relative search volumes (RSV) for osteoporosis searches in the USA and worldwide. LOESS (Locally Estimated Scatterplot Smoothing) was used to decompose a time series into its seasonal component, trend component, and residual component. We also analysed RSV values in US states according to income levels. Results. It is seen that RSV values in the USA and the world have been in a decreasing trend from 2004 to 2014, but after 2015, they have been in an increasing trend. According to the results of the cosinor analysis, RSV values in the US and worldwide are highest in the fall months and lowest in the summer months. Significant differences were found in search trends between seasons in both the US and the world (p<0.05). There is no statistically significant difference in RSV values by income level worldwide and in the USA (p>0.05). Conclusion. Osteoporosis appears to be a global health problem and a major focus of attention, both in the US and around the world. Health strategies to increase osteoporosis awareness can be planned to address different income groups, taking into account regional and seasonal effects. -
Images in Endocrinology
Cristea C, Rotariu DI, Leustean L, Ungureanu MC
Pituitary Bright Stalk – The Damming-Up EffectActa Endo (Buc) 2022 18(1): 125-126 doi: 10.4183/aeb.2022.125
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Book Review
Gussi l
Yen and Jaffe's Reproductive EndocrinologyActa Endo (Buc) 2005 1(1): 126-126 doi: 10.4183/aeb.2005.126
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Notes & Comments
Ucak R, Turkyilmaz Mut D, Kaya C, Yilmaz Ozguven B, Kabukcuoglu F, Uludag M
Is Repeat FNAB Necessary For Thyroid Nodules with ND / UNS Cytology?Acta Endo (Buc) 2022 18(1): 127-133 doi: 10.4183/aeb.2022.127
AbstractContext/Objective. The standard approach is to perform repeat FNAB (rFNAB) in thyroid nodules with nondiagnostic (ND) / insufficient (UNS) cytology. However, due to the nature of these nodules, recurrent FNABs may also be insufficient. Therefore, by comparing the clinicalradiological- pathological parameters of nodules with a definite diagnosis of excision, we questioned the possibility of patient management without rFNAB. Methods. Clinical-radiological parameters of 275 nodules belonging to 264 patients in the ND/UNS aspiration group with definite pathological diagnosis after surgery were determined. Under the guidance of these parameters, those with and without rFNAB were compared. Results. The incidence of malignancy was found to be significantly higher in nodules without rFNAB compared to nodules with rFNAB (p = 0.036). In addition, the incidence of malignancy in BC-1 nodules without rFNAB was significantly higher than in nodules with rFNAB result also BC-1 (p = 0.009). In all cases, nodule size smaller than 10 mm and border irregularity were found to be statistically significant for malignancy (p <0.020, p <0.002). When looking at the distribution of rFNAB results, a significant correlation was observed with female gender, solid component, hypoechogenicity, border irregularity and halo loss around the nodule in patients with BC-4,5,6 cytology results (respectively, 0.005 / 0.031 / 0.001 / 0.012 / 0.004). Conclusion. rFNAB did not show the expected effect in ND / UNS nodules. We recommend direct surgical excision without rFNAB for nodules with border irregularity, solid structure, halo loss and hypoechogenicity, which should be considered more important in female patients. -
Images in Endocrinology
Aguilar-Shea AL, Vera-Garcia M, Sierra-Santos L
Bullosis diabeticorumActa Endo (Buc) 2009 5(1): 129-129 doi: 10.4183/aeb.2009.129